There are many species of antioxidants, but not all are created equal. Although Pterostilbene is a phenol that is chemically related to Resveratrol it differs by increased bioavailability and and a well-defined activity in the body.

Pterostilbene is isolated from the stem heartwood of Pterocarpus marsupium while resveratrol is extracted from the root of Reynoutria japonica (synonyms Fallopia japonica and Polygonum cuspidatum). Although they are both antioxidants, resveratrol and pterostilbene complement each other by the outcomes of their specific antioxidant effects.

• The antioxidant effect of resveratrol provides for activation of calorie restriction mimetic and telomere maintenance factors with main outcomes being cardiovascular and anti-aging effects.
• Pterostilbene acts as an antioxidant by activating AMPK (AMP-activated protein kinase) that regulates energy metabolism, and by activating Sirtuin 1. Obesity and aging diminish Sirtuin 1 (1, 2). Sirtuin 1 is NAD dependent, therefore increasing NAD+ levels can enhance the effect of pterostilbene.

SIRT1 is one of the most important transcriptional factors that drives many cellular activities, like energy metabolism, cell survival, DNA stability, inflammation, and circadian rhythms (3).

The added Quercetin is itself an antioxidant complementing Resveratrol and Pterostilbene. At the same time when Quercetin and Medium Chain Triglycerides (MCT) are associated with Resveratrol and Pterostilbene, the overall bioavailability of these antioxidants can be potentiated. Added specialized Piperine extract – Bioperine® (Sabinsa Corp.) – helps to increase resveratrol delivery (4).

References:

1. Pterostilbene Monograph, Alternative Medicine Review, Volume 15, Number 2
2. Yi-Rong Li et al., Effect of resveratrol and pterostilbene on aging and longevity, International Union of Biochemistry and Molecular Biology, Volume 44, Number 1, January/February 2018, Pages 69–82
3. Alessandra Stacchiotti et al. – Resveratrol snd Sirt1 Activators for the treatment of Aging and Age-related diseases, http://dx.doi.org/10.5772/intechopen.78977-2018, Chapter 6
4. James M. Smoliga and Otis Blanchard, Enhancing the Delivery of Resveratrol in Humans, Molecules 2014, 19, 17154-17172

Did you know

In general, Sirtuins help regulate your cellular health, but they can only function in the presence of NAD+. Sirtuin 1 is particuarly important as it is a protein encoded by the SIRT1 longevity gene.

Who can benefit?

All adults concerned with the body's aging process, and wanting to feel and look younger.

As part of an anti-aging protocol/program

Before gym or exercise activity

Recommended dose

Adults take 2 capsules one time per day.

Cautions:

For prolonged use, consult a health care practitioner. If symptoms persist or worsen, or if new symptoms develop, discontinue use and consult a health care practitioner. Ensure to drink enough fluid before, during, and after exercise. Consult a health care practitioner prior to use if you have diabetes, a history of cancer, or suffer from an immune system disorder (e.g. Crohn's disease, myasthenia gravis, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematous, HIV/AIDS, etc.) or you are taking medications to suppress the immune system (immunosuppressive medications) If you are taking prescription medications, consult a health care practitioner prior to use. Do not use this product if you are pregnant or breastfeeding or if have a known allergy/hypersensitivity to cow's milk. May cause a flushing, tingling and/or prickling sensation of the skin, in which case, reduce the dose.

Do not use if seal is broken. Keep out of reach of children.

Keep sealed, store in a cool, dry place at 15–25ºC.